Shane tries to dull her pain in the hopes that she can forget about Carmen and Jenny's blossoming relationship. Tina comes between Helena and her ex over the custody of their kids and offers a glimmer of hope to Bette. Dana and Alice call everyone to The Planet to announce their new relationship.
After Dennis and Camille Burnett are found dead in their home, the only survivor is their twenty-year-old daughter, Rachel. Goren and Eames initially suspect that someone connected with the Marinko family had the Burnetts killed, since they were in witness relocation, but the detectives soon realise that the connection isn't the parents, it's the daughter. Suspicion then turns to the daughter's biological parents and her birth father's very jealous wife.
George Sr. tries to find a way to attend an anniversary dinner for Lucille while Michael deliberately offends Ann's devout Christian parents. Tobias goes overboard performing his "Mrs. Featherbottom" persona.
The residents of Wisteria Lane all attend the unfortunate funeral of Juanita Solis as Carlos and Gabrielle fret over their financial and court issues. Lynette befriends a deaf woman, Alisa Stevens, whose children also attend Barcliff Academy with Porter and Preston, but her newfound friendship is quickly put to the test. Meanwhile, Bree encounters more trouble with her son Andrew when it comes to disciplining him and lastly, Susan finds herself attracted to Edie's hunky new contractor, but Edie doesn't want her to go with him as a favor to their fragile friendship.
After Shelbyville accuses Springfield of being hicks, Marge convinces the townspeople to fund a Frank Gehry-designed concert hall, which is then converted to a prison when the concert hall goes bankrupt on opening night. Meanwhile, Bart and Lisa investigate Snowball II's recent weight gain.
Doc Cochran advises Dan and Johnny how to help Swearengen's recovery. Thriving business at a new brothel leads to a startling discovery by Tolliver. Merrick gets a scoop from Yankton about gold claims. Bullock's badge comes in handy for Commissioner Jarry.
The surgical staff tries to be optimistic as a young woman clings to life after a brutal attack. Meanwhile Meredith puts her career on the line to save a newborn in the hospital nursery, and the other interns learn that it takes more than just medical knowledge to be good at their jobs.
When Francis and Piama choose to celebrate Francis' 21st birthday at the house, Hal is reminded of a promise he made to his son as a young child, involving a motorcycle trip that Lois quickly forbids. Hal and Francis have no choice but to sneak off for their wild adventure, leaving their women behind. Meanwhile Malcolm, Dewey and Reese are held captive in their own home by a bully.
Randy makes an odd request of Sue. He asks her for some help with woman he is about to meet there is one problem in the correspondence Randy and his date have shared over the computer she forgot to tell Randy she was deaf. Sue now has to accompany Randy on his date to help him with the sign language.
Leonardo and Usagi arrive in the Battle Nexus hoping for a way to reunite the four turtles and their master. But they find the Battle Nexus under the control of the evil Ultimate Drako and Master Splinter is his prisoner.
After the "Atlantis" ship disappeared, Optimus Prime and Megatron head to the moon where it's hiding while Vector Prime and the kids locate the Omega Lock. Will the Autobots prevent the Decepticons from getting the Omega Lock? And what does a side-changing Transformer named Sideways have planned?
The Mystery Kids head for a NASCAR-like championship race where mayhem is taking place on the racetracks.
The Doctor takes Rose on her first voyage through time: to the year five billion, when the Sun is about to expand and swallow the Earth. She is cautious and soon starts to question her reasons for joining The Doctor. But amongst the powerful alien races gathering to watch on Platform One, a murderer is at work. Who is controlling the mysterious and deadly metal spiders?
When Audrey and Walter go out of town for spring break they leave Drake, Josh, and Megan at home by themselves. When they are at the Premiere they overhear a couple saying that they don't have a place to stay. Drake and Josh take advantage of this opportunity and say that their vacant house is a hotel. Meanwhile, Megan is attempting to get Drake and Josh to treat her like a guest.
The cases of Harmon Rabb, former Navy fighter pilot, and his fellow lawyers of the U.S. Navy's Judge Advocate General's office.
Zack and Cody have two pet rats as a science project. Mr. Moseby gives the twins tickets to a Red Sox's game to get them away from the hotel. Then a hotel inspector seizes control of the Tipton, because of Zack's mistake. London has a dog party for Ivana and Maddie has to plan.
When Kim discovers that Ron has missed practice and their daily trip to Bueno Nacho, she finds out that television is the reason he has been busy. She manages to get him and they head out to stop Dr. Drakken and Shego to get back the Pan-Dimensional Vortex Inducer, but when his laser goes awry and sucks them into a television world, Ron’s newfound knowledge of television may just prove useful.
When Billy and Mandy's school is preparing for a big game, Mindy entrusts the care of the school's mascot, Fluffy Cat, to Billy, to protect him from being kidnapped by the rival team, the Booty Heads. At Billy's house, Fluffy Cat is a disaster, so Billy's mom throws him into the basement, where the cat gets inside Grim's trunk, absorbing its powers. A giant Fluffy Cat appears just before the game wreaking havoc.
As Billy is tired of all the rules in his house, he cannot resist the urge to try his father's new motorcycle. The motorcycle breaks down, and Billy asks Grim to repair it. Grim's scythe turns the motorcycle into a wild, supernatural vehicle, which transforms Billy's parents and everyone around it into undead creatures and motorized monsters. Mandy makes Billy tell the truth about breaking the motorcycle in the first place, at which point his parents and everyone else return to normal.